Research Labs - Molecular Neurobiology

A major topic of research focuses on the analysis of release patterns of brain originated proteins in case of acute or chronic CNS disorders. In addition to the standard neurobiochemistry equipment we run a fully automated LIASON® analyzer which was made available by Sangtec Medical. Part of research, therefore, concerns testing of new surrogate markers of brain damage in clinical and experimental settings.

Studies were conducted in the fields of

  The results of a variety of recent studies show that early release patterns of glial and neuronal brain tissue derived proteins

Recent publications:

Ehrenreich, H., Kästner, A., Weissenborn, K., Streeter, J., Sperling, S., Wang, K.K., Worthmann, H., Hayes, R.L., von Ahsen, N., Kastrup, A., Jeromin, A., & Herrmann, M. (2011). Circulating damage marker profiles support a neuroprotective effect of erythropoietin in ischemic stroke patients. Molecular Medicine, 17, 1306-1310.

Ehrenreich, H., Weissenborn, K., Prange, H., Schneider, D., Weimar, C., Wartenberg, K., Schellinger, P.D., Bohn, M., Becker, H., Wegrzyn, M., Jähnig, P., Herrmann, M., Knauth, M., Bähr, M., Heide, W., Wagner, A., Schwab, S., Reichmann, H., Rieckmann, P., Schwendemann, G., Dengler, R., Kastrup, A., Gefeller, O., Diener, H.C., & Bartels, C., for the EPO Stroke Trial Group (2009). Recombinant human erythropoietin in the treatment of acute ischemic stroke. Stroke, 40, e647-e656.

Herrmann, M. (2008). Molekulare Marker einer Hirnschädigung - Proteomik. In: Gauggel, S. & Herrmann, M. (Eds.) Handbuch der Neuro- und Biopsychologie. Göttingen: Hogrefe-Verlag, pp. 113-120.

Vissers,J.L.M., Mersch,M.E.C., Rosmalen,C.F., Geel,W.J.A., Lamers,K.J.B., Rosmalen,F.M.A., Swinkels,L.M.J.W., Thomsen,J., & Herrmann,M. (2006). Rapid immunoassay for the determination of glial fibrillary acidic protein (GFAP) in serum. Clinica Chimica Acta, 366, 336-40.

Ehrenreich,H., Aust,C., Krampe,H., Jahn,H., Jacob,S., Herrmann,M. & Sirén,A.L. (2004) Erythropoietin: Novel approaches to neuroprotection in human brain disease. Metabolic Brain Disease, 19, 195-206.

Herrmann,M. & Ehrenreich,H. (2003) Brain derived proteins as markers of acute stroke – Their relation to pathophysiology, outcome prediction and neuroprotective drug monitoring. Restorative Neurology and Neuroscience, 21, 177-190.

Herrmann,M., Curio,N., Jost,S., Grubich,C., Ebert,A.D., Fork,M.L. & Synowitz,H. (2001) Release of biochemical markers of damage to neuronal and glial brain tissue is associated with short- and long-term neuropsychological outcome after traumatic brain injury. Journal of Neurology, Neurosurgery, and Psychiatry, 70, 95-100

Herrmann,M., Johnsson,P. & Romner,B. (2003) Molecular markers of brain damage – current state and future perspectives. Restorative Neurology and Neuroscience, 21, 75-77.

Herrmann,M., Vos,P., Wunderlich,M.T., de Bruijn,C.H.M.M. & Lamers,K.J.B. (2000) Release of glial tissue specific proteins after stroke: A contrastive analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke, 31, 2670-2677.

Herrmann,M., Jost,S., Kutz,S., Ebert,A.D., Kratz,T., Wunderlich,M.T. & Synowitz,H. (2000) Release patterns of neurobiochemical markers of brain damage after traumatic brain injury is associated with intracranial pathology as demonstrated in cranial computed tomography. Journal of Neurotrauma, 17, 113-122.

Herrmann,M., Ebert,A.D., Galazki,I, Wunderlich,M.T., Kunz,W.S. & Huth,C. (2000) Neurobehavioral outcome prediction after cardiac surgery: The role of neurobiochemical markers of damage to neuronal and glial brain tissue. Stroke, 31, 645-650.

Herrmann,M., Huth,C. & Ebert,A.D. (2000) Pathophysiological predictors of the short- and long-term neurobehavioral outcome of cardiac surgery with extra-corporeal circulation. In: Baykut,D. & Krian,A. (Eds.) Current perspectives of extracorporeal circulation. Darmstadt: Steinkopff-Verlag. 103-115.

Wunderlich,M.T., Ebert,A.D., Kratz,T., Goertler,M. Jost,St. & Herrmann,M. (1999) Early neurobehavioral outcome after stroke is related to release of neurobiochemical markers of brain damage, Stroke, 30, 1190-1195.

Herrmann,M., Curio,N., Jost,St., Wunderlich,M.T., Synowitz,H. & Wallesch,C.W. (1999) Protein S-100B and neurone specific enolase as early neurobiochemical markers of the severity of traumatic brain injury. Restorative Neurology and Neuroscience, 14, 109-114.

Herrmann,M., Ebert,A.D., Tober,D., Hann,J. & Huth,C. (1999) A contrastive analysis of release patterns of biochemical markers of brain damage after coronary artery bypass grafting and valve replacement and their association with the neurobehavioral outcome after cardiac surgery. European Journal of Cardio-thoracic Surgery, 16, 513-518.

Current research projects:

Details will follow